Mesenchymal Stem Cells and Cartilage Tissue Engineering

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Robert L. Mauck, MD, discusses a series of micromechanical experiments offering new insights into colony dependent heterogeneity in mixed parent and colony derived mesenchymal stem cell populations cultured under chondrogenic conditions using single cell mechanical profiling.
The objective of these studies was to identify stem cell subpopulations capable of producing mechanically robust matrix in the clinical treatment of osteoarthritis.